Dr. Lei Huang, MD, is currently an Associate Research Professor of Neurosurgery at Loma Linda University. As a research faculty member, her work encompasses a range of cerebrovascular diseases, including subarachnoid hemorrhage (SAH), with a particular emphasis on pathophysiology and conducting translational research using animal models. Her preclinical studies aim to uncover molecular mechanisms and identify potential therapeutic targets to ultimately improve outcomes for patients suffering from these life-threatening conditions. 

Please tell us your background, where you are from, schooling, etc.?

I received my medical degree and completed residency training in Neurology in China. Following a research fellowship, I began my research career in a neuroimaging laboratory at Loma Linda University, focusing on MRI-based biomarkers for brain injury. I later joined the Center for Neuroscience Research, where I expanded my work to include translational studies on cerebrovascular diseases.

What led you to become involved with brain aneurysm research?

My medical background has provided me with a strong clinical foundation and a deep understanding of the significance of brain aneurysms and subarachnoid hemorrhage. I became actively involved in brain aneurysm research after joining the Center for Neuroscience Research, where I had the opportunity to work with Dr. John Zhang, a renowned neuroscientist in translational stroke research. This experience has been instrumental in shaping my research focus and deepening my commitment to advancing the understanding and treatment of subarachnoid hemorrhage.

In the simplest terms, what is the purpose of your project?

The project aims to study how abnormal Piezo1 activation, triggered by increased brain pressure after brain aneurysm rupture, may lead to delayed brain damage. This could help find new ways to treat patients and improve their recovery after subarachnoid hemorrhage.

In the simplest terms, what do you hope will change through your research findings?

To advance therapeutic strategies aimed at improving clinical outcomes in patients affected by subarachnoid hemorrhage.

Why is the funding you are receiving through the Brain Aneurysm Foundation so important?

The funding from the Brain Aneurysm Foundation is crucial because it supports the research that can lead to new discoveries and treatments. With this support, we can explore innovative ideas that may improve the outcomes of patients affected by brain aneurysms and subarachnoid hemorrhage.